Rest, followed by trunk and abdominal strengthening exercises, is the most common non-surgical treatment for spondylolysis and spondylolisthesis. A physical therapist can often help you get back on your feet and teach you how to do these exercises correctly without exacerbating your symptoms. If your leg pain is severe, you can also take an anti-inflammatory medication. Braces are rarely required, but they may be beneficial in reducing your symptoms. Injections of anti-inflammatory cortisol may also be beneficial.

Surgery to repair the defect in the pars interarticularis is only required for people with spondylolysis after non-surgical measures such as physical therapy and exercises have failed to relieve symptoms. Surgery may be used to directly repair the pars defect in younger people without a slip; in older people or those with some degree of instability, a spinal fusion may be required. If there is slippage, the two main goals are to unpin the nerves and to stabilize the spine internally. It is also possible to return things to normal alignment.